Nicotine addiction is a disease

Tobacco use, including in the form of tobacco products, is a significant threat to human health.

The composition of tobacco smoke includes substances that have toxic, mutagenic and carcinogenic properties:

- ammonia;

- carbon monoxide;

- volatile carcinogenic carbohydrates;

- radioactive polonium; - nicotine; - soot;

- tar;

- hydrogen sulfide;

- hydrocyanic acid.

Tobacco use increases the risk of developing severe cardiovascular, bronchopulmonary, gastrointestinal, endocrine and oncological diseases, the reproductive system and other diseases.

Associated with smoking and diseases of the digestive system: chronic gastritis, peptic ulcer, etc. Smokers have reduced the effectiveness of the treatment of peptic ulcer and 12 duodenal ulcer.

Smoking has a negative effect on carbohydrate and fat metabolism, on the function of the gonads in men.

Smoking can be the cause of: hearing loss, eye diseases, tobacco amblyopia, tooth enamel disorders, and decreased immunity. With prolonged smoking, visual acuity is lost, the sense of smell and taste buds are dulled.

Smoking pregnant can cause:

- An increase in spontaneous abortion and premature birth;

- an increase in the frequency of prematurity and underweight at birth.

Nicotine addiction is a disease.

Nicotine is a plant alkaloid, just like heroin and cocaine. It causes the development of psychological and physical addictions, affecting the human behavioral reactions, albeit to a lesser extent than drugs.

Once in the brain, nicotine interacts with receptors, and as a result, d opamine is released, a substance that has a positive stimulating effect on the central nervous system. A smoking person has a “smoked - enjoyed” reflex, which gradually becomes addicted. The longer the smoking experience, the more nicotinic receptors in the brain, the higher the degree of nicotine addiction. With long-term use of nicotine, the number of nicotine receptors in the brain increases, and in order to get the same feeling of pleasure, you need to take more nicotine.

In large doses (60 mg.), Nicotine causes paralysis of the respiratory and cardiovascular systems. Death occurs in the same way as with an overdose of drugs.

The most obvious sign of nicotine dependence is the appearance of withdrawal symptoms when smoking is stopped. Negative symptoms are possible such as: headache, malaise, weakness, increased anxiety, lowering blood pressure, irritability, sleep disturbance and others. In most cases, it is these feelings that prevent smoking cessation.

If you quit smoking, the body immediately begins the recovery process. As harmful substances are removed, the risk of cardiovascular disease is reduced. And although the process is slow, it is irreversible.

Refusing a bad habit gives a feeling of victory, improves self-esteem, the ability to more subtly feel the taste of food, a feeling of fresh breath, improved health. Do not forget that this eliminates the risk of secondhand smoke for family members. The chances that your children will smoke will decrease. The positive list is increasing every year, as medical science reveals more and more facts related to the negative effects of tobacco. Therefore, the biggest service you can do for your body is to get rid of smoking and breathe clean air again with a full breast.

Quitting smoking is not easy, but possible.

By the way. Sometimes a weak erection is the result of a combination of psychological and physiological problems, but this situation is rare. Such a mixed type accounts for only 5% of all cases.

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Nicotine withdrawal

In the first weeks after quitting tobacco, withdrawal symptoms of nicotine addiction may occur. These symptoms manifest themselves in different ways and are most severe in the first days after quitting. Sleep disturbances, arrhythmia, mood decline, headache, digestive disorders, increased irritability and anxiety, excessive sweating, changes in appetite, general anxiety, impaired alertness and working capacity - these symptoms do not always manifest all at once, their intensity and duration are different in different people.

There is no reason to fear withdrawal symptoms,

they pass already in a couple of weeks and cause inconvenience only at the beginning of the throwing process. If the nicotine addiction is too great to quit on your own, we advise you to use the help of a consultant, with whom you choose the treatment method for nicotine addiction.

For the treatment of nicotine addiction, both nicotine replacement treatment (nicotine chewing gum and skin patch) and pill treatment are used - bupropion and varenicline. The last two prescription drugs are prescribed by the doctor.

Nicotine replacement treatment

Nicotine replacement treatment may be required with moderate or severe dependence on the Fagerström test . Most of all, nicotine patches and nicotine chewing gums are used as an aid in quitting smoking. Replacement drugs can be bought at a pharmacy without a prescription, but it’s wise to contact your family doctor, nurse, or quit counselor when drawing up a competent treatment plan. As a rule, nicotine replacement treatment is most effective in combination with competent counseling - this is a free service that does not require a doctor's appointment.

Nicotine patches

When using patches, the body evenly receives nicotine, the rapid rise and decrease in the concentration of nicotine in the blood, characteristic of smoking, disappears. Thus, you can better accustom your body to lower levels of nicotine. After every 3 weeks, you should gradually change the patches to others, with a lower content of nicotine.

Nicotine patches are effective for 16 hours (so-called daily) or 24 hours (so-called daily). The 16-hour patch adheres to the skin more firmly and acts during wakefulness without disturbing falling asleep or sleeping. By morning, the concentration of nicotine in the blood is close to zero, so additional treatment in the form of nicotine gum may be required. The 24-hour patch is transparent and inconspicuous; when glued, the patch should be pressed for 1-2 minutes with a hot hand. It acts both during wakefulness and during sleep, it can cause difficulty falling asleep and vivid dreams, but morning nicotine hunger is lower.

Nicotine gum

There are nicotine gum strong (4 mg) and weak (2 mg) action. Nicotine chewing gum is used if necessary during the weaning period, that is, 8-12 weeks. Constant consumption of nicotine gum can keep nicotine addiction, therefore it is not recommended to quit smoking only with gum. Then it should be abandoned. The best combination is a nicotine patch and, if necessary, a weak nicotine gum. Chewing gum should be chewed slowly until a sharp and strong taste or burning sensation in the throat. Then it is necessary to interrupt the chewing, remove the chewing gum by the cheek and resume chewing when the spicy taste disappears. Repeat the cycle. Getting used to the right chewing technique usually takes a couple of days.

It should be remembered that a side effect of nicotine gum can be nausea or hiccups, trembling hands, heart palpitations. Also, nicotine that enters the stomach when chewing can cause irritation in the stomach. With constant chewing, there is also the danger of an overdose of nicotine.

TOBACCO TREATMENT

Tobacco smoking is a major modifiable risk factor for death worldwide. Smoking tops the list of leading causes of noncommunicable diseases along with arterial hypertension, hypercholesterolemia, alcohol abuse, lack of physical activity and unhealthy diet. The contribution of smoking to the overall mortality rate is 17.1%, and to the total loss due to disability - 13.4%. Despite this, in Russia among the adult population (over 15 years old) 60% of men and 15.5% of women smoke, in Belarus about 30% of the population smokes. In the world there are quite convincing examples of the effective fight against smoking. So, in the USA, 20.8% of adults currently smoke, and in the 60s of the XX century there were 44% of them, i.e. smoking prevalence decreased by more than 2 times. In 1965, the number of smokers was 3 times higher than the number of people who stopped smoking, today, the number of former smokers exceeds the number of smokers. It is important that the prevalence of smoking is reduced among patients with a high risk of cardiovascular complications. Thus, according to the EUROASPIRE I-III study, the prevalence of smoking in European countries among patients at particularly high risk with coronary heart disease decreased by 10% over 10 years. Unfortunately, many people, even among doctors, perceive smoking as just a bad habit, and not as a modifiable risk factor that increases the overall risk of death to the greatest degree, and nicotine addiction is not like a disease (in ICD-9-CV code 305.1), requiring treatment. the prevalence of smoking in European countries among patients at particularly high risk with coronary heart disease has decreased by 10% over 10 years. Unfortunately, many people, even among doctors, perceive smoking as just a bad habit, and not as a modifiable risk factor that increases the overall risk of death to the greatest degree, and nicotine addiction is not like a disease (in ICD-9-CV code 305.1), requiring treatment. the prevalence of smoking in European countries among patients at particularly high risk with coronary heart disease has decreased by 10% over 10 years. Unfortunately, many people, even among doctors, perceive smoking as just a bad habit, and not as a modifiable risk factor that increases the overall risk of death to the greatest degree, and nicotine addiction is not like a disease (in ICD-9-CV code 305.1), requiring treatment.

Most smokers want to quit smoking and have tried repeatedly.

Nicotine addiction is a chronic condition similar to other types of addiction to any substance, requiring repeated interventions to achieve and maintain persistent smoking cessation. Nicotine contained in tobacco causes the development of a persistent adherence to smoking. After several weeks of daily smoking, cessation is usually accompanied by withdrawal. Nicotine acts as a complete agonist of nicotinic acetylcholine receptors (n-AChR) in the central nervous system, activates dopaminergic pathways in the mesolimbic system of the brain and thus promotes the development of attraction and dependence. In chronic smokers who quit smoking, dopamine secretion is reduced. It has been experimentally shown that some subtypes of n-AChR transmit the primary effects of nicotine in the brain. Subtypes consisting of two? 4- and three? 2 components, are most sensitive to nicotine, reaching 50% of maximum activation at a nicotine concentration of 0.1 to 1 μmol / L. It is believed that the 4 4 ​​components are responsible for sensitization to nicotine effects, their enhancement and tolerance, while the 2 2 components are associated with the development of dependence. Dopamine, the release of which is stimulated by nicotine, also activates glutamatergic and? -Aminobutyric neurons containing n-AChR, which can have a stimulating effect on smokers. Dopamine is a “neurotransmitter of pleasure,” and its release during tobacco smoking determines the sense of satisfaction from smoking. The smoker's body needs nicotine - without it, symptoms of withdrawal appear, which makes you smoke again. reaching 50% of maximum activation at a nicotine concentration of 0.1 to 1 μmol / L. It is believed that the 4 4 ​​components are responsible for sensitization to nicotine effects, their enhancement and tolerance, while the 2 2 components are associated with the development of dependence. Dopamine, the release of which is stimulated by nicotine, also activates glutamatergic and? -Aminobutyric neurons containing n-AChR, which can have a stimulating effect on smokers. Dopamine is a “neurotransmitter of pleasure,” and its release during tobacco smoking determines the sense of satisfaction from smoking. The smoker's body needs nicotine - without it, symptoms of withdrawal appear, which makes you smoke again. reaching 50% of maximum activation at a nicotine concentration of 0.1 to 1 μmol / L. It is believed that the 4 4 ​​components are responsible for sensitization to nicotine effects, their enhancement and tolerance, while the 2 2 components are associated with the development of dependence. Dopamine, the release of which is stimulated by nicotine, also activates glutamatergic and? -Aminobutyric neurons containing n-AChR, which can have a stimulating effect on smokers. Dopamine is a “neurotransmitter of pleasure,” and its release during tobacco smoking determines the sense of satisfaction from smoking. The smoker's body needs nicotine - without it, symptoms of withdrawal appear, which makes you smoke again. their enhancement and tolerance, while the? 2-components are associated with the development of dependence. Dopamine, the release of which is stimulated by nicotine, also activates glutamatergic and? -Aminobutyric neurons containing n-AChR, which can have a stimulating effect on smokers. Dopamine is a “neurotransmitter of pleasure,” and its release during tobacco smoking determines the sense of satisfaction from smoking. The smoker's body needs nicotine - without it, symptoms of withdrawal appear, which makes you smoke again. their enhancement and tolerance, while the? 2-components are associated with the development of dependence. Dopamine, the release of which is stimulated by nicotine, also activates glutamatergic and? -Aminobutyric neurons containing n-AChR, which can have a stimulating effect on smokers. Dopamine is a “neurotransmitter of pleasure,” and its release during tobacco smoking determines the sense of satisfaction from smoking. The smoker's body needs nicotine - without it, symptoms of withdrawal appear, which makes you smoke again. and its release in the process of smoking tobacco determines the sense of satisfaction from smoking. The smoker's body needs nicotine - without it, symptoms of withdrawal appear, which makes you smoke again. and its release in the process of smoking tobacco determines the sense of satisfaction from smoking. The smoker's body needs nicotine - without it, symptoms of withdrawal appear, which makes you smoke again.

It should be noted that smoking by the strength of the emerging dependence is equal to heroin and cocaine, smoking cessation is associated with withdrawal symptoms, including mood changes, anger, irritability, depression, impaired concentration.

One of the most important points in the fight against tobacco smoking is the widespread introduction into practice of methods to combat nicotine addiction, the effectiveness of which has been confirmed by modern criteria in randomized controlled trials, meta-analyzes, and systematic reviews.

The recommendations for the treatment of smoking and nicotine addiction highlight 10 key points that must be considered in practice:

1. Tobacco addiction is a chronic disease that often requires repeated interventions and repeated attempts to stop smoking. However, there are effective treatments that can significantly increase the likelihood of prolonged smoking cessation.

2. It is imperative that clinicians and healthcare professionals constantly identify and document tobacco smoking status and treat every smoker.

3. The treatment of tobacco dependence is effective in a wide range of subpopulations (gender, age, state of health, educational level, etc.). Clinicians should encourage each patient to try to stop smoking, give appropriate advice and recommend medications that have been proven effective.

4. Short courses of treatment for nicotine addiction are effective. Clinicians should offer every smoking patient at least a short treatment with methods effective from the perspective of evidence-based medicine.

5. Individual, group and telephone consultations are effective, and their effectiveness increases with the intensification of treatment (medication). Two components of counseling are particularly effective, and clinicians should use them when dealing with patients trying to stop smoking:

practical advice (answers to questions / training),

social support as part of the treatment.

6. There are a number of medications with proven effectiveness in the treatment of nicotine addiction, and the clinician must make every effort for their use by patients trying to quit smoking, except when there are medical contraindications or special groups in which there is insufficient evidence of effectiveness (pregnant women who use chewing and snuff, low-smoking and adolescents).

Seven first-line drugs (the first 5 contain nicotine) significantly increase the likelihood of prolonged smoking cessation:

nicotine chewing gum, nicotine inhaler, nicotine lollipops, nicotine nasal spray, nicotine-containing patch, varenicline, bupropion MD *.

The clinician should also consider the possibility of using combinations of drugs in cases where monotherapy is not effective enough and at the same time, the efficacy of the combination proposed for prescribing is greater than monotherapy.

7. Consultations and drug therapy are individually effective for the treatment of nicotine addiction, but in combination their effectiveness is increased. Therefore, clinicians should try to ensure that each patient receives both consultative and medical care.

8. Telephone counseling on smoking cessation issues is effective in the general population and can significantly expand the circle of patients. Therefore, doctors and healthcare professionals must implement this method in everyday practice.

9. If the smoker is currently not inclined to make an attempt to stop smoking, it is necessary to motivate him to such attempts in the future.

10. The treatment of nicotine addiction is effective both clinically and economically. The provision of counseling and medication for the treatment of nicotine addiction free of charge for the patient increases the likelihood of a successful outcome. Insurers and health workers should include methods that have proven efficacy in their insurance plans, as they are economically viable.

In World for the treatment of smoking, cytisine is also registered - a herbal preparation made in Bulgaria containing an alkaloid isolated from the plant Cytisus laburnum (broom). The mechanism of action is similar to nicotine. When smoking while taking cytisine, the effect of nicotine is combined with the effect of cytisine, which leads to the appearance of unpleasant symptoms of nicotine overdose. This causes the patient to gradually give up smoking without experiencing withdrawal symptoms, since the effect of nicotine is replaced by the action of cytisine.

Drugs that are not recommended for the treatment of nicotine addiction due to the lack of evidence of their effectiveness for these purposes are serotonin reuptake inhibitors (sertaline, fluoxetine), anxiolytics (buspirone, diazepam),? -Blockers (anaprilin), opioid receptor antagonists (naltrexone), silver acetate , mecamylamine.

All the methods of drug treatment of nicotine addiction recommended above, according to meta-analyzes, significantly superior to placebo.

Fig. 1. A total assessment of the effect of pharmacotherapy on smoking cessation.

Smoking cessation was determined by the most stringent criteria. Data adjusted for age, gender, and daily cigarette requirements. CI - confidence interval.

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Miralash eyelash enhancer accelerates lashes growth and lengthens their life span. First results can be seen after only 4 weeks of use, full results after 3 months of use. The best specialists working on Miralash formula used natural extracts to guarantee effectiveness and ensure safety. Also special brush makes application very easy.
Ingredients:Aqua, Propanediol, Panthenol, Glycerin, Biotinoyl Tripeptide-1, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dechloro Dihydroxy Difluoro Ethylcloprostenolamide, Disodium EDTA, Ethylhexylglycerin,Niacinamide,Panax Ginseng Root Extract, Phenoxyethanol, Propylene Glycol, Sodium Hydroxide, Soluble Collagen, Urtica Dioica (Nettle) Extract.
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